Platelet Physiology & Inflammation

Unravelling blood platelets’ contribution to pathophysiological mechanisms related to endogenous stress (transfusion & aging) with a focus on circulation and cardiovascular systems.

Combination of ex vivo, in vitro, and in vivo approaches to decipher platelet thrombo-inflammatory responses involved in these mechanisms.

– Thrombo-inflammatory role of platelets in a transfusion context: Improvement and evaluation of platelet concentrate preparation processes to optimize transfusion efficiency and develop personalized transfusion.

– Inflammatory role of platelets in aging context : figure out the fundamental mechanisms governing platelet thrombo-inflammatory responses during ageing to define new molecular targets to regulate platelet’s response.

She recently transferred her knowledge on Extracellular Vesicles in the design of biomaterial applications and is a scientific partner in NANOTRAP project in the frame of the Graduate School, EUR Manutech Sleight. Moreover, Anne-Claire is co-supervising Lily Bruyere, with Martin Kilian (CIRI, GIMAP) on her PhD project dealing with Extracellular Vesicles in Sjögren syndromes. Last but not least, she supervised Mailys Portier on her Engineer project (effect of sphingolipid on transfusion and aging) and Chloé Heranney on her PhD project dealing with effect of lipid mediator on platelet and endothelium physio-pathology.

• 2008 – 2010 : Cellular Biology TD/ TP on the 4 tissues ( volume : 96h/ year) Claude Bernard University Lyon, France
• 2015 : Biochemestry TD/TP (volume : 90h), Laval University, Quebec, Canada
• 2019-2021  (281h total), Aix Marseille University, Pharmacy School, France:
  • Fundamental Biochemestry  TD/TP (2nd & 3rd year of Pharmacy school) UE22.02 – Biochemestry & UE32.08 : Biochemestry markers
  • Genetic CM ( 10h- 3rd year of Pharmacy school) UE 32-09C ; UE DFSASP (4th year, UE filière internat)
  • Immunology (3rd year of Pharmacy school) UE 32-01
  • Initiation to vascular research ( 25h- 3rd years of Pharmacy school) UE 32-10C
• 2023 -… Immunology (4th year DU-Pre Master degree) Courses on extracellular vesicle in immunity, Jean Monnet University, Saint Etienne, France
• 2024-… Thrombosis, Hemostasis and Vascular Biology ( Master 2 i-santé)
  • Atherosclerosis & Atherothrombosis
  • Vascular Biology
  • Extracellular Vesicle in vascular biology

I am research scientist (Chargé de recherche) at French Blood Establishment (EFS) affiliated at INSERM U-1059 SAINBIOSE Unit. I work in vascular biology, with a special focus on blood components and platelets, since 2021.

I received my PhD in Immunology & Microbiology in 2015 at Laval University (Québec, Canada). Then I performed several post doc at Laval University (Québec, Canada) between 2015-2016; at Karolinska institutet (Stockholm, Sweden) between 2016-2017; at Heart Institute Ottawa University (Ottawa, Canada) between 2017-2019. Since my return in France, I was appointed as assistant professor at Pharmacology faculty in Aix-Marseille University, in C2VN unit between 2019-2021. I got, in 2021, my permanent position as junior scientist &Principal Investigator at EFS & SAINBIOSE

Key word : Platelet, neutrophil, immune cells, endothelium, inflammation, lipid mediator, extracellular vesicle, senescence, cell death

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