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Mathieu Simon, PhD

Postdoctoral Researcher
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mathieu.simon[@]emse.fr
Academic interests

I am interested into the application of mechanical principles to study the behaviour of biological structures/architectures developed by Nature with a general aim to advance healthcare. I started by studying the elasticity-morphology relationships in bone to understand how conditions such as diabetes, osteogenesis imperfecta, osteoporosis or ageing impair the bone mechanical function.

I recently shifted to the soft tissue realm. I now develop numerical simulations using FEniCSx to study how the aorta architecture influence its susceptibility to undergo dissection. I have a particular interest into bridging experimental data (imaging and mechanical testing) and numerical methods (image analysis and computational simulations).

Teaching

I am currently co-supervising two student projects in Master programs. The first investigates relations between 2D histological sections and 3D CT scans of aortic tissue. The second uses physic-informed machine learning approaches to predict mechanical behaviour of soft tissue samples from surface scan.

Background

I studied mechanical engineering at the University of Applied Science in Fribourg (Switzerland) and performed my Bachelor thesis at the University College London. Then, I continued with a Master in Biomedical Engineering at the University of Bern, where I also completed my PhD. My doctoral research focused on multi-scale bone morphology-elasticity relationships in ageing and disease. I started my postdoctoral research at the Ecole des Mines de Saint-Etienne (France) in June 2025.

Publication