The focus of his basic research is mechanobiology of bone cells (mainly osteoprogenitors, osteoblasts/cytes). A central question is what is a defective cell mechanotransduction: a sensor, transductor, memory or sensitivity problems? He contributed to described role of integrins, cytoskeleton, RhoGTPases, YAP in bone cells mechanosensing in particular in microgravity (8 space experiments as PI). He recently transfers this knowledge in the design of mechanoactive surfaces for bone & dental implants (#LASIMP) and biomaterial applications (#NANOTRAP) in the frame of the Graduate School, EUR Manutech Sleight. His applied research (surface engineering & imaging) responds to ageing population demands and consists in developing innovative technologies for improving bone imaging (#LUMEX/LUNA) and 3D bone morphometry measurements (#MALBOT) for patients.

Coordinator of the Biomedical Engineering track / Master of Health Engineering (MSc) since 2012, a Master track of the #EUR Manutech Sleight Graduate School since 2017. Resp. of Biomedical Engineering seminar (6ECTS) project 20h/S3, Co Resp. MusculoSkeletal physiology seminar (6ECTS), teaching Biology and imaging of osteocytes 4h/S3. Resp. Mechanobiology seminar (3ECTS) teaching 12h/S3. Biomechanics of cells, YAP.TAZ and Piezo, stem cell memory – niche stiffness, mechano-inflammation. Teaching Cell & Molecular Biology, 20h M1/S1, Analysis of prot-prot interactions, basis of spatialomics, critical analysis of research papers.

Education manager of 1^st year (L1) of the Bachelor in Health Science, Resp. Cell & Tissue Engineering module (5ECTS), teaching 18h/S2, L2 Resp. Cell Biology module (4ECTS), teaching 12h/S1; L3, co-resp. Biopathology module (4 ECTS) teaching osteo-immunology, mineral stress and EVP 12h/S1 Resp. Cell Analysis module (2ECTS), teaching cytometry.image analysis 8h/S5, Resp. Biomaterials module, (3ECTS) 12h/S1. Teaching Tissue Engineering 12h/S5.

Practical work: Imaging: 12h Confocal Imaging (L2), 24h Videomicroscopy (L3), Light-sheet imaging (M1). Image treatments & Analysis: 18h ImageJ/Fiji basics (L3), ARIVIS 3D and VR (M1)

Teaching for 1^st year medical students, L1 PASS, Cell Biology and Histology, 25h /S1

Elected member of CFVU & Academic council of UJM (B Rank) since 2022.

Alain Guignandon has been Associate Professor in cell biology at the Department of Bio-Engineering for Health, Medical School since 2008 and at the EUR Manutech-Sleight Graduate School since 2017. He completed his PhD in bone physiology at Jean Monnet University (#UJM) in 1997. He spent 12 months as a postdoc at the University of Liege (GIGA center) with an ESA fellowship before assuming a position as study engineering (IGE) at UJM for space experiments coordination until 2008. He obtained accreditation to direct research (HDR) in 2010.

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