Obesity is a significant risk factor for OA because it increases the mechanical burden on weight-bearing joints and facilitates a pro-inflammatory state that exacerbates joint degeneration. The coexistence of obesity and OA, termed “obesity-compounded osteoarthritis,” represents a particularly challenging clinical scenario characterized by heightened pain and disability.

Ketogenic diets, which are characterized by their high fat and low carbohydrate content, have gained attention for their potential therapeutic benefits in treating various chronic diseases, including epilepsy, diabetes, and obesity. Some researchers, including our team, have explored the possibility that a ketogenic diet may be a useful intervention for managing pain associated with osteoarthritis (OA), as it has been shown to reduce inflammation, oxidative stress, and pain in various preclinical and clinical studies. In our research, we employ a comprehensive approach that involves the use of both in vivo murine studies and in vitro investigations using cultured primary chondrocytes and cell lines (ATDC5). This integrated methodology enables us to thoroughly examine the cellular and molecular mechanisms underlying the effect of diet on the progression of OA in obesity.

LICENCE SCIENCES POUR LA SANTE PARCOURS INGENIERIE SANTE & ESANTE 3A – ACCES SANTE (3MD610_200), UE8 BIOLOGIE DU DEVELOPPEMENT II (TP=16H) (semester1)

LICENCE SCIENCES POUR LA SANTE 2A- ACCES SANTE(2MD600_200), UE9 BIOLOGIE DU DEVELOPPEMENT(TP=6H) (semester2)

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