My mission is to better understand how bone tissue adapts to mechanical constraints, but also to energetic and metabolic challenges, all of which being interdependent, and to propose strategies for preventing bone loss of spaceflight, immobilization or ageing. I participated to the clinical validation in osteoporotic patients of a high-resolution peripheral quantitative computed tomograph (HRpQCT) for bone exploration and to a microCT for rodent bone exploration. I described the adaptation of the skeleton in rats and mice after spaceflight exposure (6 missions), in cosmonauts and astronauts (MIR and ISS space stations). I studied the bone loss mechanisms in ground-based analogs: rodent models, human during bedrest or dry immersion, patients. Kinetics of bone loss was established in a mouse model, which is currently used to establish recommendations of physical exercise and nutrition programs to maintaining the health of astronauts. In a current 2-month bedrest campaign at Medes space clinic in Toulouse, I am leading a project gathering four teams with expertise in cardiovascular, bone, metabolism and imaging technologies to extend our knowledge and help revolutionise indicators of bone and cardiovascular health in control volunteers and test the efficiency of artificial gravity alone or coupled with physical exercise.

After a stay at NASA in 1993 as research fellow in the lab of Emily Morey-Holton (Ames Center, California) where I worked on animal and cellular models related to space, I continued my scientific activity at University Jean Monnet, Saint-Etienne.

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