Osteoporosis is a disease characterized by a reduced bone quantity and quality leading to fractures and disability. This condition arises from an imbalance in bone remodeling where resorption outweighs formation, ultimately leading to bone loss. Along with its resulting fractures, osteoporosis is a major cause of disability and morbidity.

Nacre, a marine-derived material, is renowned for its bone-related properties, serving not only as a calcium source but also as a reservoir of active peptides that promote bone formation and suppress resorption.

In this thesis project, we will continue the identification and synthesis of active peptides from nacre in collaboration with a team from the Institute of Natural Substance Chemistry in Gif-sur-Yvette, Paris.

Initially, we will screen the identified nacre peptides using a screening tool based on a reporter gene and gene promoters involved in osteoblastic stimulation and/or in osteoclastic resorption in two different cellular systems.

Our aim is to uncover the molecular mechanisms by which these peptides stimulate osteoblasts differentiation and inhibit osteoclasts resorption, as well as the specific signaling pathways they trigger in bone cells.

Through gaining insight into how nacre combats bone loss, this initiative lays the foundation for the development of innovative peptide-based therapies for osteoporosis.

LICENCE SCIENCES POUR LA SANTE PARCOURS INGENIERIE SANTE & ESANTE 3A – ACCES SANTE (3MD610_200), UE8 BIOLOGIE DU DEVELOPPEMENT II (TP=16H) (semester1)

LICENCE SCIENCES POUR LA SANTE 2A- ACCES SANTE(2MD600_200), UE9 BIOLOGIE DU DEVELOPPEMENT(TP=6H) (semester2)

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