Platelet Physiology & Inflammation

Unravelling blood platelets’ contribution to pathophysiological mechanisms related to endogenous stress (transfusion & aging) with a focus on circulation and cardiovascular systems.

Combination of ex vivo, in vitro, and in vivo approaches to decipher platelet thrombo-inflammatory responses involved in these mechanisms.

– Thrombo-inflammatory role of platelets in a transfusion context: Improvement and evaluation of platelet concentrate preparation processes to optimize transfusion efficiency and develop personalized transfusion.

– Inflammatory role of platelets in aging context : figure out the fundamental mechanisms governing platelet thrombo-inflammatory responses during ageing to define new molecular targets to regulate platelet’s response.

• 2008 – 2010 : Cellular Biology TD/ TP on the 4 tissues ( volume : 96h/ year) Claude Bernard University Lyon, France
• 2015 : Biochemestry TD/TP (volume : 90h), Laval University, Quebec, Canada
• 2019-2021  (281h total), Aix Marseille University, Pharmacy School, France:
  • Fundamental Biochemestry  TD/TP (2nd & 3rd year of Pharmacy school) UE22.02 – Biochemestry & UE32.08 : Biochemestry markers
  • Genetic CM ( 10h- 3rd year of Pharmacy school) UE 32-09C ; UE DFSASP (4th year, UE filière internat)
  • Immunology (3rd year of Pharmacy school) UE 32-01
  • Initiation to vascular research ( 25h- 3rd years of Pharmacy school) UE 32-10C
• 2023 -… Immunology (4th year Master degree) Courses on extracellular vesicle in immunity, Jean Monnet University, Saint Etienne, France

I am research scientist (Chargé de recherche) at French Blood Establishment (EFS) affiliated at INSERM U-1059 SAINBIOSE Unit. I work in vascular biology, with a special focus on blood components and platelets, since 2021.

I received my PhD in Immunology & Microbiology in 2015 at Laval University (Québec, Canada). Then I performed several post doc at Laval University (Québec, Canada) between 2015-2016; at Karolinska institutet (Stockholm, Sweden) between 2016-2017; at Heart Institute Ottawa University (Ottawa, Canada) between 2017-2019. Since my return in France, I was appointed as assistant professor at Pharmacology faculty in Aix-Marseille University, in C2VN unit between 2019-2021. I got, in 2021, my permanent position as junior scientist &Principal Investigator at EFS & SAINBIOSE

Key word : Platelet, neutrophil, immune cells, endothelium, inflammation, lipid mediator, extracellular vesicle, senescence, cell death

• Orcid 
• Pubmed
• Google Sholar