Involvement of Blood-Brain Barrier Efficacy in the Healthy and Diseased Brain in the context of sleep apnea and neurodegenerative disease

My research  concern the Study of BBB permeability in the context of sleep apnea. Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a respiratory disorder associated with repeated sequences of hypoxia during sleep. The high prevalence of this syndrome is between 4% and 20%, depending on the population, but unfortunately it is still under-studied. This raises the question of public health screening, particularly in the elderly population where the prevalence is highest. This pathology leads to numerous neurological and vascular alterations. It increases the risk of cerebrovascular events (stroke/TIA) four fold. Neurological disorders are caused by the blood-brain barrier (BBB). This physical, impermeable biological barrier separates the “blood” compartment from the “brain” compartment. Any change in the functioning of the BBB can allow pathogenic or inflammatory agents to pass inappropriately from the blood to the brain.  This leads to alterations in the central nervous system, and can generate neurological diseases in the long term.

In this context :

• Development of cellular models of biological barriers: Blood-brain barrier – Blood Tumor Barrier Microfuilidic models in the context of hypoxia and more recently in the context of  cancer cells
• Evaluation of paracellular transport and metabolic transport :  Expression of ABC transporters (Pgp, MRP, BCRP), cellular detoxification (GSH) , study of  intermittent hypoxia and  pH regulation, and  stress oxidative.
• Isolation and characterisation of exosomes particles from sera patient and study of interaction with BBB
•  In vivo Fragmentation model on rodent : Study of  neuro-cardiovascular effect of sleep

All my teaching has always been cross-disciplinary, combining biophysical issues with those of cell biology, and this cross-disciplinary approach has been at the heart of my research and teaching activities. At the moment, I teach courses on the biophysical aspects of membrane transport and more fundamental courses in cell biology linked to my research activity (oxidative stress, hypoxia, apoptosis, cancerology).  The idea is to get them to integrate these concepts and help them with Critical Reading of Scientific Articles.  This course will be progressive from the first year of the Bachelor’s degree to the Master’s degree that I have in charge for the University.

We have set up a Research and Training Department to coordinate and monitor our training courses, which I am currently responsible for, with around 400 students in training, and which I am managing for 4 years 2023-2027. I have attached a provisional summary of our bac+5 training, I am in charge of this department for 4 years. and also, of the master Health Engineering since 2016, of the bachelor degree in health Sciences since 2021 date of the creation.

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