SAINBIOSE INSERM U1059VASCULAR DYSFUNCTION & HEMOSTASIS

Research Team

“We develop strategies to understand and to treat vascular dysfunctions and hemostasis “

Translational Research for vascular dysfunction & hemostasis

Heart and vessels in a spherical shell. Polygonal design of lines and dots. Blue background.

The DVH team gathers together scientists from different domains (engineering, biology, physiopathology, pharmacology and surgery) engaged in translational research on vascular dysfunctions and hemostasis in specific bio-stress situations (aging, surgery, pregnancy, etc.). The DVH team is led by S Avril.

The DVH team develops a comprehensive approach to vascular biostress that takes into account both the blood, the vessel wall and blood-vessel interactions. The research focuses on the 3 themes of SAINBIOSE:

  • Understanding of biostress, including the role of mechanobiology in vascular dysfunctions and also the role of inflammation in coagulation
  • Development of dynamic models reproducing in silico the regulatory processes involved in situations of cardiovascular biostress in order to propose therapeutic innovations based on digital twins
  • Precision medicine with the aim of translational research aimed at providing patients with the fundamental and technological advances made by the team.

Vascular dysfunctions are underpinned by highly variable risk situations, thrombotic and/or hemorrhagic risk factors, and by medications that themselves generate thrombogenic or hemorrhagic conditions. Therefore, DVH develops models considering the combination of factors linked to patients themselves due to their own physiological and anatomical characteristics in order to enable personallized medicine.

To give an example, among others, the DVH team has made significant scientific breakthroughs regarding the role of mechanics in thoracic aortic aneurysms. We showed that the risk of aneurysm rupture is significantly increased when the age-induced stiffening of the vascular wall. We developed patient-specific digital twins of the fluid-structure interactions and biological processes involved in aortic aneurysms. This work was supported by several ERC grants and lead to the creation of 2 start-ups.

Research axes

BIOLOGICAL ACTIVITY OF INHALED PARTICLES

BIOPI
Aims

Our aim is to improve the understanding of the fate of inhaled (nano)particles in terms of biodistribution, biological activity (therapeutic or toxicological) and biopersistence.

Academic collaborations
  • Lyon University, FR : Professor P Miossec
  • Leeds University, UK : Professor F Ponchel
  • Northwestern University, USA : Doctor A Martin
  • Nantes University, FR : Doctor L Beck

AUTONOMIC NERVOUS SYSTEM

SNA
Aims

We aim at optimizing the regulation of the ANS through physical activity to address cardiovascular disorders.

Academic collaborations
  • Centre national des études spatiales (CNES)
  • Clinique de l’espace, Toulouse (MEDES)
  • MATHEIS, Lyon
  • Lab Hubert Curien, CRNS UMR, St Etienne
  • University of Waterloo, Canada: Pr RL Hughson

PHARMACOLOGY & THROMBOSIS

Aims

Our aim focuse on hemostasis pharmacology and multiparametric personalized pharmacology,

Academic collaborations
  • Centre national des études spatiales (CNES)
  • Clinique de l’espace, Toulouse (MEDES)
  • MATHEIS, Lyon
  • Lab Hubert Curien, CRNS UMR, St Etienne
  • University of Waterloo, Canada: Pr RL Hughson

PLATELET & INFLAMMATION

Aims

We investigate the inflammatory platelet response in biostress situations such as infection but also in transfusion, and aging

Academic collaborations
  • Lyon University, FR : Professor P Miossec
  • Leeds University, UK : Professor F Ponchel
  • Northwestern University, USA : Doctor A Martin
  • Nantes University, FR : Doctor L Beck

Soft Tissue Biomechanics

STB
Aims

We aim to carry out fundamental investigations in the domain of mechanical identification of soft tissues and prostheses, with strong interactions with medical device industries and with clinicians.

Academic collaborations
  • Centre national des études spatiales (CNES)
  • Clinique de l’espace, Toulouse (MEDES)
  • MATHEIS, Lyon
  • Lab Hubert Curien, CRNS UMR, St Etienne
  • University of Waterloo, Canada: Pr RL Hughson

Team

Hubert Marotte
Professor, Director of Unit, Team LeaderStephane Avril, PhD
STB
David Eglin
Professor, Team LeaderSilvy Laporte, PhD
Guillaume Courbon
Axe leaderJeremie Pourchez, PhD
Frederic Coutant
Research Director, Axe LeaderFabrice Cognasse, PhD
Nathalie Douard
Professor, Axe co-leaderFrederic Roche, MD, PhD
Alain Guignandon
Associate ProfessorClaire Morin, PhD
Donata Iandolo
ProfessorPatrick Mismetti, MD, PhD
Alexandre Karkas
ProfessorValérie Forest, PhD
Marie Helene Lafage Proust
Researcher (Chargé de recherche EFS)Anne-Claire Duchez, PhD
Luc Malaval
Professor, co-leader AxeHughes Patural, MD, PhD
David Marchat
Associate ProfessorFanette Chassagne, PhD
Marthe Rousseau
ProfessorLaurent Bertoletti, MD, PhD
Maura Strigini
Associate professorSophie Perinel Ragey, MD, PhD
Thierry Thomas
ProfessorAurélie Scalabre, MD, PhD
Laurence Vico
ProfessorNathalie Perek, PhD
David Marchat
Associate ProfessorAlexandra Vallet, PhD
Marthe Rousseau
ProfessorBrigitte Tardy, MD, PhD
Maura Strigini
ProfessorCéline Chauleur, MD, PhD
Thierry Thomas
Associate ProfessorAntoine Giraud, MD, PhD
Laurence Vico
ProfessorTiphaine Barjat, MD, PhD
David Marchat
Associate ProfessorDavid Charier, PhD
Marthe Rousseau
Associate ProfessorEdouard Ollier, MD, PhD
Maura Strigini
Associate professorEmilie Chalayer, MD, PhD
Thierry Thomas
Associate ProfessorDavid Hupin, PhD
Laurence Vico
Physiotherapist researcherPierre Labeix

Sponsors

ANR
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UJM
mines
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FondationUJM
logoArthritis
MEDES
ESA
CNES
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