This research group focuses on platelet physiology and the analysis of their inflammatory response to biostress, investigating the role of platelet function in the pathophysiological mechanisms through which biostress, whether exogenous (in an infectious context) or endogenous (in a transfusion context), can lead to pathology, with a particular emphasis on pulmonary and cardiovascular systems. Platelets are recognized not only for producing immunomodulatory soluble molecules but also for binding self and non-self molecules involved in various stages of innate or adaptive immunity. Their investigations, combining ex vivo, in vitro, and in vivo approaches, enhance the understanding of platelet responses to biostress.

Specifically, the group examines the inflammatory role of platelets in a transfusion context, aiming to improve and evaluate the processes of platelet concentrate preparation to optimize transfusion outcomes and develop personalized transfusion strategies. Similarly, in an infectious context, they delve into the fundamental mechanisms regulating platelet thrombotic and inflammatory responses during infection to identify new molecular targets and define novel inhibitors of platelets’ anti-infectious inflammatory response. This multidisciplinary approach not only advances our understanding of platelet functions in disease contexts but also paves the way for innovative therapeutic interventions targeting platelet-mediated inflammation.